Studies on 1-alkyl-2(1H)-pyridone derivatives. XXVII. The Diels-Alder reactions of 1-methyl-2(1H)-pyridone with methyl acrylate and acrylonitrile.

5-Methyl-2-pyridone

The crystal structure of the title compound, C(6)H(7)NO, is stabilized by inter-molecular N-H⋯O hydrogen bonds, resulting in inversion dimers. The structure is further consolidated by weak C-H⋯O hydrogen bonds.

Appendix 1. Diels-Alder Reactions

One of the most efficient methods (high yield, controlled stereochemistry, diverse functionality) to construct rings from smaller fragments is via cycloaddition reactions. The reverse reaction, namely splitting of a ring into smaller fragments is termed a cycloreversion reaction is also an important synthetic tool. (For example, in the present experiment it is the cracking of cyclopentadiene di...

Sequential Diels–Alder/[3,3]-sigmatropic rearrangement reactions of β-nitrostyrene with 3-methyl-1,3-pentadiene

The tin(IV)-catalyzed reaction of β-nitrostyrene with (E)-3-methyl-1,3-pentadiene in toluene afforded two major nitronic ester cycloadducts in 27% and 29% yield that arise from the reaction at the less substituted diene double bond. Also present were four cycloadducts from the reaction at the higher substituted diene double bond, two of which were the formal cycloadducts of (Z)-3-methyl-1,3-pen...

DISCOVERY OF NEW SELECTIVE DIELS-ALDER REACTIONS USING ETHYLENE: PRODUCTION OF PTA FROM HMF VIA OXIDATION ROUTE 5.1 New ethylene Diels-Alder-dehydration reactions using 5-methyl-2-furoic acid (MFA) and methyl 5-methyl-2-furoate (MMF) as dienes

Studies on alkyl-xanthine derivatives. II. Pharmacokinetic and pharmacodynamic studies of a new bronchodilator, 1-methyl-3-propylxanthine (MPX).

A new xanthine derivative bronchodilator, 1-methyl-3-propylxanthine (MPX), and 1-methyl-3-butylxanthine (MBX) were synthesized. We evaluated their relaxant effects on tracheal smooth muscle isolated from guinea pigs and pharmacokinetic characteristics in rats using 1,3-dimethylxanthine (theophylline, TPH) as the reference drug. Dose-dependent relaxant effects were observed in the concentration ...